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However, the signaling pathways and molecules inter-linking DDR, DNA repair and circadian clock genes are unclear

10.1038/clpt.2011.150 23 HeckerM.FrahmN.BachmannP.DebusJ

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This activation enhances the cellular defense against oxidative stress and suppresses the iron-mediated ROS production, which are pivotal in the pathogenesis of osteoarthritis