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Description

Saudi journal of biological sciences

11:819-825.: 10.2147/DMSO.S181154

Activated TBK1 regulates phosphorylation of transcription factors such as interferon (IFN) regulatory factor 3 (IRF3), interferon-regulatory factor 7 (IRF7), and NF-B, which then translocate into the cell nucleus to promote the secretion of type I IFNs and proinflammatory cytokines [5,6,7]