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In vitro , metformin has anti-tumor properties, inhibiting proliferation and inducing apoptosis on uterine leiomyoma cells via the activation of AMPK, followed by the inhibition of the mTOR pathway (Li et al., 2013

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Seminal work demonstrates that systemic BCG vaccination triggers intestinal lamina propria-resident innate memory cells via microbiota-dependent spatiotemporal metabolic reprogramming, identifying a paradigm for distal mucosal immune memory establishment (Jeyanathan et al., 2022)