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found that the combination of PTT with immunogenic coreshell Au@Se NPs could enhance the positive expression of Hsp70 in cancer cells, and Au@Se NPs could effectively stimulate the maturation of DCs with antigen-presenting functions, reminding us the potential application of Se NPs in antitumor immunity ( Figure 2 Se NPs enhance natural killer cell functions Natural killer (NK) cells play a vital role in innate immune responses to cancer and infection, which is highly related to their surface receptors for recognizing tumor cells and pathogen-infected cells, leading to the activation of receptor-triggered cytotoxicity and cytokine production

128 Disruption of gut barrier integrity and microbial translocation: The accelerator of liver disease progression Pathophysiological changes in gut barrier structure and function As a key physical and immunological defense line separating intestinal lumen contents from the hosts internal environment, the integrity of the gut barrier suffers systemic destruction during the progression of liver diseases

Overnight cultures were subcultured 1:100 into fresh LB medium supplemented with 50 g/mL kanamycin and grown at 37 C, with 230 rpm shaking until an OD 600 of ~0.8 was reached

Ethics statement The studies involving humans were approved by Ethics Committee of the Area Vasta Nord Ovest Toscana (Italy)