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Associations of baseline levels of TMAO, choline and L- carnitine with cognitive function over time was estimated using a linear mixed model adjusted for demographics, vascular risk factors (hypertension, atrial fibrillation, diabetes mellitus, dyslipidemia, history of coronary artery disease), life style factors (smoking, body mass index), stroke severity, and ischemic stroke subtype

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Fortunately, a wealth of recent studies show that by activating AMPK, metformin plays a major role in preventing age-related disorders including cancer, cardiovascular disease, obesity, and neurocognitive decline