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Taken together, these findings support the concept that creatine not only serves as a bioenergetic substrate but also acts as a signaling molecule that orchestrates mitochondrial biogenesis, dynamics, and epigenetic adaptationpositioning it as a multifaceted agent for enhancing mitochondrial health within the framework of predictive, preventive, and personalized medicine

All differential metabolites/biomarkers identified were used as an input set for pathway analysis

therefore, it relies on dietary sources and efficient absorption from the gastrointestinal tract

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