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Gene set enrichment analysis (GSEA) was performed using the fgsea R package (version 1.29.1) 36

The development of depression-like behavior is consolidated by IL-6-induced activation of locus coeruleus neurons and IL-1-induced elevated leptin levels in mice

In addition, some researchers have used immunotherapy and synthetic biology to design living bacteria, combining immunotherapy expression with optimized lysis mechanism, so that living bacteria can carry nanobodies back to the core of necrotic tumors, grow to a critical density, and lyse, effectively and continuously releasing therapeutic drugs in the tumor microenvironment