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Brouquet A, Abdalla EK, Kopetz ES , Garrett CR, Overman MJ, Eng C, Andreou A, Loyer EM, Madoff DC, Curley SA, Vauthey JN

It works on the melanin production at the tyrosinase enzymatic level, and it reduces pigment production at the surface level

Beyond heavy metals, other environmental contaminants such as fine particulate matter (PM2.5), pesticides, and industrial chemicals can also disrupt the structural integrity of the ECM and promote aberrant tissue remodeling [108,109]