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Conversely, primary or secondary defects of the intestinal barrier can lead to excessive entrance of dietary or microbe-derived macromolecules, which are putative contributors to the pathogenesis of a spectrum of human diseases, including food allergy and inflammatory bowel diseases (IBDs), and could even be related to autoimmune diseases and metabolic syndrome

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The rs1799837 (APOA1) and rs1800588 (LIPC) SNP variants represented the major determinants of HDL cholesterol efflux capacity in women, while rs2230806 (ABCA1) and rs5082 (APOAII) variants were key determinants in men (207)