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These effects can be severe such as stroke, encephalitis, and lack of oxygen or mild as in the impairment in sustained attention

Moreover, the stiffness of the extracellular matrix can influence DNA methylation through protein kinase C -dependent nuclear transport of DNMT3L, thereby connecting biomechanical signals to the epigenetic regulation of stem cell pluripotency

Lens cells need to continually extrude intracellular protons, which accumulate due to inward movement of positive ions from the extracellular space and lactic acid from anaerobic glycolysis

Flavonoids, anthocyanins, polyphenols, among others have been tested in rat and mouse models to measure gene expression levels of pathways that regulate insulin resistance (126, 127)