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Brightfield images of soft agar colonies from liver metastatic cell lines using individual shRNAs validating top 6 screen hits

This detoxification process indirectly reduces oxidative stress by removing substances that can generate free radicals

The active site was located at the centre of the bifunnel contributed by the Glu loop (flap, residues 334339), Asn loop (residues 265277), and Tyr loop (residues 163199) of each subunit and the Asp loop (latch, residues 6074) of the neighboring subunit (Fig

When the telomeres on a cells chromosomes get too short, the chromosome reaches a critical length, and the cell stops dividing (senescence) or dies (apoptosis)