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Physiol Rev (2010) 90(1):20758

544 GLP-1 has pleiotropic actions due to the extensive expression of GLP-1 receptors (GLP-1R) in multiple organs, including microglia and astrocytes across various brain regions, thus is being explored for its potential in neurodegenerative diseases

Although it is still unknown why these BCAA levels are elevated and why they associate with insulin resistance, a dysfunctional BCAA catabolism may be one of the underlying factors