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In vivo, following intravenous administration (10 mg/kg ARV771 equivalent) in MDA-MB-231 tumor-bearing BALB/c nude mice, the PGD7 NPs showed 2.0-fold higher tumor accumulation at 36 h post-injection compared to non-sheddable PDA7 NPs, as evidenced by fluorescence imaging

Arginase expression or activity increases in the presence of exogenous arginine (Ide et al., 2020) In the arginase pathway, ornithine and urea are formed from arginine

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