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Mechanistic and Translational Research Further investigation into the molecular mechanisms of action could help optimize clinical applications and identify novel therapeutic targets

Autoimmune conditions including Guillain-Barre syndrome and chronic inflammatory demyelinating polyneuropathy attack nerve myelin directly

In 1891, it was found to be useful to treat malaria, thus making methylene blue "the first synthetic compound ever used as an antiseptic in clinical therapy and the first antiseptic dye to be used therapeutically," according to the authors of a Medicinal Research Reviews paper on the compound

Cells were treated with 50 M BCS for 8 days, 6-mercaptopurine (6-MP, 500 nM) for 24 hours, and/or methotrexate (MTX, 5 nM) for 24 hours