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Nanoparticles in combating neuronal dysregulated signaling pathways: recent approaches to the nanoformulations of phytochemicals and synthetic drugs against neurodegenerative diseases

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At low intracellular concentrations of methionine, remethylation of the metabolic product is favored over transsulfuration, and methionine is conserved

Further exploration of other in vivo tumor models as well as clinical studies is necessary to determine whether the limited dependence of some tumor cells on glutamine anaplerosis is associated with select oncogenic contexts or tissues of origin, or whether it reflects glutamine availability in the specific tissue environments