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Nat Rev Rheumatol 10 , 561566 (2014)

These compounds may influence neurotransmitters, stress response pathways, and cognitive processes such as focus, memory, and mood regulation

The authors research whether TB-500 may tone down this signaling and suggest that the peptide may increase the level of miR-146a, a small regulatory RNA molecule whose role may be to act as an internal brake on inflammatory signaling pathways