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In addition to fecal microbiota transplantation, other interventions aim to modify the gut microbiome composition through diet or bacteriophage therapy

We were able to resolve high-resolution ligand-bound structures for analogs 43 (ID: pdb_000013CV, 1.95 ), 53 (ID: pdb_000013CW, 2.48 ), 60 (ID: pdb_000013DF, 1.84 ), and 69 (ID: pdb_000035YH, 2.60 ) bound to UCHL3 ( Figure 5 , ligand density in Figure S1 and crystallographic data statistics in Table S1 S3 )

Adipose-selective PGC-1 ablation induces rapid insulin resistance alongside decreased thermogenic gene expression and mitochondrial dysfunction (120)

65 This protection is achieved through a variety of biological processes, including interactions with transition metals, neutralization of free radicals, modification of the activity of different enzymes, and impacts on intracellular signaling pathways and gene expression