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Heme enters CydDC via the membrane and rotates by 180 To map possible routes of heme entry, we carried out multiple atomistic MD simulations, focusing on the behavior of heme near lipid bilayer surfaces (70% palmitoyloleoyl phosphatidylethanolamine (POPE), 25% palmitoyloleoyl phosphatidylglycerol (POPG) and 5% cardiolipin) and the substrate-binding pocket (Fig