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Surprisingly, it was observed that none of the ten skin-lightening cosmetics analysed were manufactured in Nigeria

Third, 5mC-containing sequences can undergo mutations by deamination, UV exposure, or interaction with certain carcinogenic chemicals.[11] Significantly, all three changes often occur in cancer, which shows that a lack of epigenetic balance is a crucial part of cancer development.[12] Excluding CpG -rich areas, most CpGs in the genome are 80% methylated, while the usual CpG methylation level in cancer is 40%60%.[13] However, it is still unclear how DNA methylation changes occur in a cancerous epigenome and what biological effects may result from reduced methylation [Figure 1]

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