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Mitochondria dysfunction in sepsis Morphological alterations The description of morphological impairment of mitochondria was first reported in a canine model of septic cardiomyopathy decades ago, and it is characterized by swelling, loss of cristae, cleared matrix, internal vesicles, and rupture of the inner and outer membranes [6]

Among these drivers, metabolic factors including obesity, insulin resistance, and dyslipidemia, play a key role by facilitating the sustained mobilization, trafficking, and homing of immune cells into target tissues 15,16

Symposia and Recent Lectures Wright RS

13 CHOP encodes a regulatory subunit of an eIF2-directed phosphatase complex that helps ER-stressed cells recover protein synthesis