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When these affinity-enhancing mutations were added to full-length rat amylin, all three mutated rat amylin analogs showed enhanced potency for amylin receptor 1/2 activation by 5- to 10-fold compared to endogenous rat amylin and a clinical drug pramlintide (Figure 9A, 9B and Table 3)

10.1002/aja.1001270402 187 PfeifferT.PollS.BancelinS.AngibaudJ.Krishna InavalliV

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These effects may be optimally stimulated at lower concentrations where the body interprets the signal as a gentle prompt rather than an emergency