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Inhibition of excessive proinflammatory cytokine release can be achieved through attenuation of NF-B activity and suppression of TNF- and IL-1 secretion, thereby maintaining a balanced level of NF-B activity and preventing an overwhelming increase in miR-155-5p levels ( 4.3 miR-29b2/c The activation of glial cells in MPTP-induced PD mice can be enhanced by the expression of miR-29b2/c

More information on BBB heterogeneity and BBB openin can be found here [120, 128]