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Across a subset of meningioma samples with paired RNA-seq data ( n = 584 patients), methylation of the promoter site cg16983159 exhibited the strongest correlation with STING expression (rho = 0.54, p 20% weight loss, neurologic symptoms, or evidence of pain/distress as per Northwestern IACUC

As a result, it acts close to its source, oxidizing nearby biomolecules, while H 2 O 2 can freely diffuse across cell membranes and oxidize molecules farther away, such as pathogen membrane lipids

The supernatants and precipitates were harvested by centrifugation at 14,200 g for 10 min at 4 C