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Acetaminophen Toxicity: How Genetic Susceptibility Combines with Environmental Factors Print Article CMAJ Phase II Reactions: Glutathione Conjugation and Mercapturic Acid Formation in Pharmacokinetics and Pharmacodynamics JoVE Core A 48 hour fast can turn standard Paracetamol into acute liver failure. Fasting depletes Glutathione, leaving the liver defenseless against toxic NAPQI. Review the latest guidelines on BMJ Best Practice: https: bestpractice.bmj.com topics en us 1010
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