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This gap prevents dose-response relationships from animals from being translated into safe and effective design of human doses for fertility

External stressors damage both structural aspects and operational capacity of the corpus luteum through modifications of genetic and epigenetic regulatory systems (138)

However, a substantial proportion of low-risk neuroblastomas with elevated MYCN expressed from a normal MYCN locus, particularly those arising in children younger than 18 months, regress spontaneously (stage 4S disease) by unknown mechanisms even when the disease is metastatic 5

The up-regulation of IGF1R signaling promotes radio-resistance in several types of solid tumors (Turner et al., 1997