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This characterization positions formate as a significant factor in the intricate interplay between the gut microbiome and CRC

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To summarize, model organisms and patient-derived cells can be used to model FRDA, but due to the technical and biological limitations, there is a need for more human FRDA-like models such as FRDA iPSC-based cells or organoids

This revealed an inverse association between the expression of AGXT and PRODH2 with hepatic fat content, with the most significant negative correlation found for AGXT ( AGXT : r = 0.1838, P = 0.0083