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Role of the Hypothalamic-pituitary-adrenal axis in health and disease

Blood tests help see if the treatment is effective and if changes are needed

In addition, AS-IV inhibited intestinal FXR signaling, reduced intestinal FGF15 expression, thereby reducing liver FXR activation, increased glucagon-like peptide-1 secretion, and ultimately suppressed SREBP-1c-mediated lipogenesis and liver steatosis (Zhai et al., 2022)