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Additionally, the specific BMP antagonist gremlin induces LOX and LOXL1-4 expression through constitutively active TGF/Smad and inducible MAPK/JNK signaling pathways, suggesting BMPs may at least partially mediate enzymatic collagen crosslinking (Sethi et al ., 2013)

Full effects may take up to 3 months, depending on the severity of the condition

Lyophilised peptides remain stable for 1224 months when frozen, but any temperature excursion above 8C during shipping or storage initiates irreversible protein denaturation