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This risk arises from a potential reduction in intrinsic factor production, crucial for B12 absorption

Since Folic Acid and Vitamin B12 play leading roles in the methylation cycle, their close-knit relationship and their impact on homocysteine has some researchers suggesting that both should be taken as supplements to prevent neural tube defects

However, it's important to note that individual results may vary, and benefits may take several weeks or months to become visible

Based on the positive results from three Phase III studies, in 2012 FDA approved topiramate/phentermine extended-release as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in eligible adults