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312 Understanding the intricate balance of ROS in tumor biology is key to developing targeted therapies that can modulate ROS levels to inhibit tumor growth effectively

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These results define the potential for AA147 to protect against glutamate induced oxidative toxicity and highlight the potential for metabolically-activated proteostasis regulators like AA147 to activate both protective ATF6 and NRF2 stress-responsive signaling pathways to mitigate oxidative damage associated with diverse neurologic diseases