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Seven pivotal studies utilizing this model have demonstrated the multifaceted neuroprotective effects of natural products, as detailed below (Table 9)

Each cohort was then treated for 14 consecutive days with twice-daily treatments with either 300 mg/kg of NHPN-1010 or an equivalent volume of saline

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Administration of the GLS1-specific inhibitors BPTES and CB-839 reduced keratinocyte proliferation and chemokine production, decreased Th17 and Th17-cell differentiation and epidermal proliferation, and improved the splenomegaly and skin lesions in a psoriasis-like mouse model (79)