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for instance, gain-of-function variants in KCNQ2 or KCNQ3 genes, which encode Kv7.2 and Kv7.3 subunits, have been associated with reduced pain sensitivity in individuals carrying a pro-excitatory Nav1.7 mutation, demonstrating how enhanced M-current can confer resilience to neuronal hyperexcitability (Estacion et al., 2023)

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Kashifard, M., Basirat, Z., Kashifard, M., Golsorkhtabar-Amiri, M., & Moghaddamnia, A