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The rate-limiting step in glutathione synthesis is the availability of cysteine, which can be obtained from the diet or synthesized de novo from methionine

Primaquine-induced hemolytic anemia: Susceptibility of normal versus glutathione-depleted rat erythrocytes to 5-hydroxyprimaquine

Figure 6 Our previous data suggested the importance of PUFA metabolism in the chronicity of DILI, thus we further analyzed the expression of genes associated with PUFA metabolism

M1 macrophages, activated by interferon (IFN)- and lipopolysaccharide (LPS) (21,22), amplify inflammatory responses and resist pathogenic infection through the production of IL-1, IL-6, IL-12, TNF- and chemokines (23-26)