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In addition, some other members of SIRTs including SIRT3, 4 and 5 display neuroprotective roles against epilepsy as a result of evidences supporting the improvement of neuronal damage for SIRT3 via scavenging ROS in mitochondria [120], protection from excitotoxicity for SIRT4 via increasing GLT-1-mediated glutamate uptake [121] and reduction of hippocampal neurodegeneration and attenuation of seizure susceptibility for SIRT5 [122]

No compound is declared a winner at the end, because the honest answer for both compounds, on the field that matters most (human efficacy), is the same: unproven

Researchers rely on these standards to help ensure product identity, purity, and consistency throughout their projects