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In addition, the down-regulation of p53, NF-B, Pim-1, and c-Myb expression, along with the Bax/Bcl2 ratio in mice, suggested that the preventive effect of FA on NTDs was also linked to its anti-apoptotic effect [149]

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Glutathione may play a role in a number of other oxidation-reduction systems.135,136 For example, Giblin and coworkers137 have demonstrated a clear link between glutathione, glutathione peroxidase, the hexose monophosphate shunt, and hydrogen peroxide breakdown