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Notably, a flow cytometry study of cells from ovarian cancer patients revealed that tumor cell proliferation, as determined by the percentage of cells in the S (DNA synthesis) phase, exhibits a highly significant 24-hour rhythm, with a peak in the mid-to-late morning that is nearly 12 h out of phase with nontumor cell proliferation in normal tissues 108 (Fig

This leads to the accumulation of -catenin and the ensuing activation of Wnt/-catenin signaling [25] (circle marked 3 in Fig

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H 2 O 2 induces hepatocyte premature senescence via the p53/progerin-dependent pathway To further delineate the molecular mechanism of oxidative stress-induced cell premature senescence, primary hepatocytes, isolated from normal rats, were cultured and stimulated with H 2 O 2 at the different doses (0, 10, 50, 100, 200 nM) for 24 h or at the dose (200 nM) from 0 to 24 h