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Similarly, a basal level of ROS is involved in cell signaling and defense

Notably, oncogenic cMyc induces the expression of proline biosynthesis enzymes while suppressing proline dehydrogenase (POX/PRODH), the first enzyme for proline catabolism (Liu et al , 2012)

Many studies combined the data for individuals who were on a variety of different single or multidrug AED regimens, and did not adjust for dose or duration of AED use