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Rogero MM, Borelli P, Vinolo MA, Fock RA, de Oliveira Pires IS, Tirapegui J

Furthermore, medium and high concentrations of BHB could antagonize diabetic nephropathy injury, potentially by causing H3K9bhb to promote the generation of MMP-2 in diabetic rats (64)

It also elaborates on how ferroptosis, in turn, exacerbates local metabolic stress and chronic inflammation through the release of Damage-Associated Molecular Patterns (DAMPs), thereby creating a vicious cycle

Firstly, the STC-induced AP model used in our study was primarily designed to mimic cholestatic pancreatitis pathogenesis ( In conclusion, our study found that promoting CPT1A expression ameliorated pancreatic acinar cell pyroptosis