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Persistent or repeated exposure to non-biodegradable or slowly cleared nanomaterials may therefore shift an initially adaptive microglial response toward chronic neuroinflammation, synaptic dysfunction, and neurodegeneration, particularly in aged or disease-susceptible brains (169)

Clinics that work in the absence of licensed practitioners, or use non-pharmaceutical-grade compounds pose a real threat to patients

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In asthma, oxidative stress can be caused by the weakening of enzymatic and non-enzymatic antioxidant mechanisms that accompany chronic inflammations ( Table 1 )