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These species are rich in cysteine and result in decreased drug availability and increased intracellular drug detoxification/inactivation, since platinum binds readily to sulfhydryl groups 29

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Disrupting the clock in male mice via adipocyte-specific genetic deletion or high-fat-diet feeding reduces complex I respiration in adipocytes, leading to suppression of the peroxisome proliferator-activated receptor and insulin signalling pathways