glutathione increases in cancer cells overproduction mediates lymphoma initiating survival and has a sex-dependent effect on lymphomagenesis Glutathione metabolism in cancer progression

Front Neurosci 12:214 Friedmann Angeli JP, Schneider M, Proneth B, Tyurina YY, Tyurin VA, Hammond VJ, Herbach N, Aichler M, Walch A, Eggenhofer E, Basavarajappa D, Radmark O, Kobayashi S, Seibt T, Beck H, Neff F, Esposito I, Wanke R, Forster H, Yefremova O, Heinrichmeyer M, Bornkamm GW, Geissler EK, Thomas SB, Stockwell BR, O'Donnell VB, Kagan VE, Schick JA, Conrad M (2014) Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

241-281 2 K

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Cancer cells also frequently alter lipid metabolism by increasing de novo fatty acid synthesis, enhancing the uptake of exogenous lipids, and remodeling lipid to produce membranes, thereby supporting rapid proliferation [22, 23]