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Thus, exposure of the brain to elevated homocysteine levels leads to overstimulation of NMDA receptors, oxidative stress, DNA damage, and endoplasmic and mitochondrial dysfunction, which may be responsible for some of the brain damage and neurodegeneration associated with AUD (26, 47)

IV therapy is used in both men and women.

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Neurotox Res 39(3):966974 Xiu Y, Field MS (2020) The roles of mitochondrial folate metabolism in supporting mitochondrial DNA synthesis, oxidative phosphorylation, and cellular function