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This paper demonstrates that the genetic architecture of ALS is largely based on rare variants and that powerful new genetic insights can arise through the analysis of large numbers of cases available through the Project MinE consortium

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In practice, the translational utility of follicular-fluid profiling will hinge less on single-marker significance than on whether cross-omic signatures remain stable under standardized pre-analytics and batch-aware normalization, enabling assay compression into reproducible panels compatible with routine ART workflows

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