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Table 2 Reported effectors and molecular pathways in glutamate cytotoxicity

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Disclosures: Lauren Rutt: Nothing to Disclose, Rebecca McCullough: Nothing to Disclose 1483 NALTREXONE USE IN PATIENTS WITH COMBINED METABOLIC AND ALCOHOL-ASSOCIATED LIVER DISEASE (METALD), PROPENSITY SCORE MATCHED STUDY Amir Hossein Gougol 1 Paul Kwo 2 C Pike 3 Saurabh Gombar 3 Gavin Hui 3 , 1 Stanford University, 2 Stanford University Medical Center, 3 Atropos Health Background: Naltrexone has demonstrated efficacy in management of alcohol use disorder

Crystallization and structure solution Crystals of as-isolated Zn-bound SOD1 were produced using previously identified conditions with the protein pre-conjugated with the ligand