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Combining PHGDH inhibitors (e.g., NCT-503) with serine/glycine restriction exacerbates DNA damage and ROS accumulation, ultimately enhancing tumor suppression in vivo

T-DXd (trastuzumab deruxtecan) has achieved clinical approval and demonstrates significant efficacy in HER2-positive CRC patients, representing a major therapeutic advance for this molecularly defined subgroup

LD-derived FAs reduce saturated FA-induced ER stress and enhance FAO, thereby reducing glycolysis to meet metabolic demands under normal conditions [95]