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NNT, NADP transhydrogenase

MMTT was performed to measure insulin resistance and glucose tolerance

The first step in decoding DILI is to classify the pattern of liver injury: Hepatocellular injury is characterized by marked elevations in alanine aminotransferase (ALT) or aspartate aminotransferase (AST), usually three times or more above the upper limit of normal (ULN)

Each RNA sample was converted to biotinylated amplified cRNA using an Illumina TotalPrep RNA Amplification kit (Life Technologies) according to the manufacturers guidelines, and cRNA quality and concentration confirmed on the Agilent Bioanalyzer 2100, as described above