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[19] It is further envisaged in the context of the present invention that each of said polypeptide monomers of the third domain has an amino acid sequence that is at least 90% identical to a sequence selected from the group consisting of: SEQ ID NOs: 17-24, or has an amino acid sequence selected from the group consisting of SEQ ID NOs: 17-24

doi: 10.1007/s00360-012-0652-0 146 Vzquez-MedinaJ

Synthetic small molecule SIRT1 activators Compared with natural products, synthetic SIRT1 activators offer several advantages, including defined molecular structures, high target selectivity, and stable pharmacokinetic profiles, making them a promising direction for the clinical application of SIRT1-targeted therapies