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Consequently, based on our results where lag times ranged from 2 to 7 h, the copper retained in the stratum corneum has the potential to become systemically available also

doi: 10.1007/978-1-4615-2584-4_89 139 Gonzalez-GayMADe MatiasJMGonzalez-JuanateyCGarcia-PorruaCSanchez-AndradeAMartinJet al

Moreover, unbound volume of distribution in the brain parenchymal cells (V u,cell ) estimated using the brain homogenate method and cerebral microdialysis can be combined with V u,brain to estimate unbound (pro)drug concentration ratio in intra- and extracellular compartments of the brain (K p,uu,cell ) (87)

At initial research-level usage , a 50 mg vial is generally sufficient for approximately one month , depending on formulation concentration and application frequency