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8 Clinical implications and conclusion The increasing global burden of liver disease necessitates effective, multi-targeted therapies

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Nicotine, cotinine and 3-hydroxy-cotinine (OH-cotinine) were measured in PBS using a quantitative liquid chromatography coupled to tandem mass spectrometry (LCMS/MS) method, based on a previously validated method for saliva (as established in 39 )

Furthermore, human Grx1 reacts twenty times faster with GSH than with L-cysteinylglycine or L-cysteine, revealing that the preference for GSH also depends on its -glutamyl moiety 19