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Komatsu N, Takayanagi H

Resveratrols glucoregulatory properties extend to the phosphatidylinositol-3-kinase/protein kinase B (PI3K/Akt) pathway, a central mediator of insulin signaling in IR (36)

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The unusual spermidine-glutathione adduct named trypanothione or N1,N8-bis(glutathionyl)spermidine found solely in these parasites functions as an electron donor in many pathways by neutralizing diverse reactive species through redox reactions, also providing reducing equivalents to intermediate molecules in other antioxidant pathways and in biosynthetic pathways such as DNA synthesis [35, 36]